Microphysical laws are time reversible, but macrophysics, chemistry and biology are not. This paper explores how this asymmetry arises due to the cosmological context, where a non-local Direction of Time is imposed by the expansion of the universe. This situation is best represented by an Evolving Block Universe, where local arrows of time emerge in concordance with the Direction of Time because a global Past Condition results in the Second Law of Thermodynamics pointing to the future. At the quantum level, (...) the indefinite future changes to the definite past due to quantum wave function collapse events. (shrink)

This chapter responds to claims that causal closure of the underlying microphysics determines brain outcomes as a matter of principle, even if we cannot hope to ever carry out the needed calculations in practice. The reductionist position is that microphysics alone determines all, specifically the functioning of the brain. Here I respond to that claim in depth, claiming that if one firstly takes into account the difference between synchronic and diachronic emergence, and secondly takes seriously the well established nature of (...) biology in general and neuroscience in particular, downward causation enables genuine causal powers to occur at higher emergent levels in biology and that causal closure is in reality an interlevel affair involving even social levels. (shrink)

The causal closure of physics is usually discussed in a context free way. Here I discuss it in the context of engineering systems and biology, where strong emergence takes place due to a combination of upwards emergence and downwards causation. Firstly, I show that causal closure is strictly limited in terms of spatial interactions because these are cases that are of necessity strongly interacting with the environment. Effective Spatial Closure holds ceteris parabus, and can be violated by Black Swan Events. (...) Secondly, I show that causal closure in the hierarchy of emergence is a strictly interlevel affair, and in the cases of engineering and biology encompasses all levels from the social level to the particle physics level. However Effective Causal Closure can usefully be defined for a restricted set of levels, and one can experimentally determine Effective Theories that hold at each level. This does not however imply those effective theories are causally complete by themselves. In particular, the particle physics level is not causally complete by itself in the contexts of solid state physics, digital computers, or biology. Furthermore Inextricably Intertwined Levels occur in all these contexts. (shrink)

It has been just over 100 years since the birth of Alan Turing and more than 65 years since he published in Mind his seminal paper, Computing Machinery and Intelligence. In the Mind paper, Turing asked a number of questions, including whether computers could ever be said to have the power of “thinking”. Turing also set up a number of criteria—including his imitation game—under which a human could judge whether a computer could be said to be “intelligent”. Turing’s paper, as (...) well as his important mathematical and computational insights of the 1930s and 1940s led to his popular acclaim as the “Father of Artificial Intelligence”. In the years since his paper was published, however, no computational system has fully satisfied Turing’s challenge. In this paper we focus on a different question, ignored in, but inspired by Turing’s work: How might the Artificial Intelligence practitioner implement “intelligence” on a computational device? Over the past 60 years, although the AI community has not produced a general-purpose computational intelligence, it has constructed a large number of important artifacts, as well as taken several philosophical stances able to shed light on the nature and implementation of intelligence. This paper contends that the construction of any human artifact includes an implicit epistemic stance. In AI this stance is found in commitments to particular knowledge representations and search strategies that lead to a product’s successes as well as its limitations. Finally, we suggest that computational and human intelligence are two different natural kinds, in the philosophical sense, and elaborate on this point in the conclusion. (shrink)

George F. Dole, Harvard Ph.D., has translated and arranged by theme a selection of passages from Swedenborg's works on life, heaven and hell, and the nature of God. This book is an accessible introduction for the reader new to Swedenborg, as well as a concise reference for those familiar with his philosophy. [Swedenborg's] philosophy is about as practical as one could ask. Ascetism is not the way to God.... A good person can be saved with any religion or with (...) no religion. "George F. Dole... has done us a great service in bringing Emanuel Swedenborg back to the attention of our distracted age." -from the foreword by Huston Smith. (shrink)

In this response, George Ellis comments on the publications of Part I. He responds first to Sara Green and Robert Batterman, before outlining his thoughts on Otávio Bueno’s piece.

In this paper, we explore the architecture of downward causation on the basis of three central cases. We set out by answering the question of how top-down causation is possible in the universe. The universe is not causally closed, because of irreducible randomness at the quantum level. What is more, contextual effects can already be observed at the level of quantum physics, where higher levels can modify the nature of lower-level elements by changing their context, or even creating them. As (...) one moves up through higher levels, contextual effects on lower levels occur on various scales within nature, which is crucial in biology in general and the brain in particular. We then argue that there are important logical downward causes.objects have causal effects on material-energetic systems. It can be shown that abstract objects have measurable effects on lower levels, which needs to be accounted for by successful explanations of real phenomena such as intentional action. Intentional action has the form of deductive causation from logical structures to human agency. Without this assumption, we would not be warranted in believing that our physical theories latch onto a universe that is essentially the way we discover it to be. Denying top-down causation on account of the idea that the universe permits only bottom-up constitution of wholes from lower-level elements leads to undermining the very possibility of knowledge and science. Thus, it can be rejected as a global form of explanation. We sketch a model for mind-body interaction according to which the various levels of a human organism together enable the emergence of mental top-down effects. They are necessary conditions for the emergence of human mindedness. Once it is clear that downward causation is a widespread natural phenomenon, the apparent mystery of mental causation is, in principle, solved. (shrink)

Is there really a hell? Should we be good simply to avoid punishment in the life hereafter? Just asking these questions theoretically doesn't get us far, George F. Dole suggests, but examining the works of someone who has been there may help. Dole refers to Emanuel Swedenborg, the eighteenth-century Swedish scientist and statesman who over the last twenty-seven years of his life had the privileged status of an observer of non-physical worlds, including hell. Swedenborg wrote that we are unconscious (...) residents of the spiritual world as well as the material world, and the hells he encountered have mirrors in our everyday lives. Within this framework, Dole examines questions about evil and hell that have plagued thinkers for centuries: Do we have freedom of choice? Do our spirits exist after death? Does an all-loving God condemn us to hell? If not, can we ourselves become irredeemably evil? What distinguishes Dole's approach to these questions is his open-mindedness and his hopefulness. Freedom and Evil brings us face to face with a God of mercy, and it is easy to believe, with Dole, that the gates of hell are not to keep people in but to keep people out. (shrink)

There has been much controversy over weak and strong emergence in physics and biology. As pointed out by Phil Anderson in many papers, the existence of broken symmetries is the key to emergence of properties in much of solid state physics. By carefully distinguishing between different types of symmetry breaking and tracing the relation between broken symmetries at micro and macro scales, I demonstrate that the emergence of the properties of semiconductors is a case of strong emergence. This is due (...) to the existence of quasiparticles such as phonons. Furthermore time dependent potentials enable downward causation as in the case of digital computers. Additionally I show that the processes of evolutionary emergence of living systems is also a case of strong emergence, as is the emergence of properties of life out of the underlying physics. A useful result emerges: standard physics theories and the emergent theories arising out of them are all effective theories that are equally valid. (shrink)

Steroid hormone receptors are ligand‐inducible transcription factors that exhibit potent effects on gene expression in living cells. Precise dissection of their mode of action at the molecular level can best be carried out in functional cell‐free systems. This article will describe the benefits of such systems and review their development up to the recent establishment of steroid receptor‐dependent in vitro transcription. Subsequent advances in our knowledge of receptor function arising from the exploitation of this powerful experimental tool will be described. (...) Particular emphasis will be placed upon two key problems: the role of steroid hormone in receptor action and the mechanisms by which steroid receptors activate gene transcription. (shrink)

Current neuroimaging techniques with high spatial resolution constrain participant motion so that many natural tasks cannot be carried out. The aim of this paper is to show how a time-locked correlation-analysis of cerebral blood flow velocity (CBFV) lateralization data, obtained with functional TransCranial Doppler (fTCD) ultrasound, can be used to infer cerebral activation patterns across tasks. In a first experiment we demonstrate that the proposed analysis method results in data that are comparable with the standard Lateralization Index (LI) for within-task (...) comparisons of CBFV patterns, recorded during cued word generation (CWG) at two difficulty levels. In the main experiment we demonstrate that the proposed analysis method shows correlated blood-flow patterns for two different cognitive tasks that are known to draw on common brain areas, CWG, and Music Synthesis. We show that CBFV patterns for Music and CWG are correlated only for participants with prior musical training. CBFV patterns for tasks that draw on distinct brain areas, the Tower of London and CWG, are not correlated. The proposed methodology extends conventional fTCD analysis by including temporal information in the analysis of cerebral blood-flow patterns to provide a robust, non-invasive method to infer whether common brain areas are used in different cognitive tasks. It complements conventional high resolution imaging techniques. (shrink)

Instead of arguing for a specific animal model, Striedter will review the history and philosophy of animal models in biomedical research, examining their various advantages and limitations.

Research regulation is a timely topic for discussions in bioethics and public health policy. This response to articles in the previous special issue of the Monash Bioethics Review emphasises the importance of having both internal and external controls of human experimentation. Unless both elements are incorporated into research ethics governance frameworks, they will ultimately fail to achieve what should be their primary goal: human subject protection.

This paper is a comment on both Bunamano and Rovelli (Bridging the neuroscience and physics of time arXiv:2110.01976. (2022)) and Gruber et al. (in Front. Psychol. Hypothesis Theory, 2022) and which discuss the relation between physical time and human time. I claim here, contrary to many views discussed there, that there is no foundational conflict between the way physics views the passage of time and the way the mind/brain perceives it. The problem rather resides in a number of misconceptions leading (...) either to the representation of spacetime as a timeless Block Universe, or at least that physically relevant universe models cannot have preferred spatial sections. The physical expanding universe can be claimed to be an Evolving Block Universe with a time-dependent future boundary, representing the dynamic nature of the way spacetime develops as matter curves spacetime and spacetime tells matter how to move. This context establishes a global direction of time that determines the various local arrows of time. Furthermore time passes when quantum wave function collapse takes place to an eigenstate; during this process, information is lost. The mind/brain acts as an imperfect clock, which coarse-grains the physical passage of time along a world line to determine the experienced passage of time, because neural processes take time to occur. This happens in a contextual way, so experienced time is not linearly related to physical time in general. Finally I point out that the Universe is never infinitely old: its future endpoint always lies infinitely faraway in the future. (shrink)